Keratin Matrix
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Healthcare Professionals

Where Healing Begins

A unique technology - a breakthrough discovery - and Molecular Biologicals has transformed the way wounds and skin diseases are treated. Through extensive research and development, we have created Replicine™ Bioactive Keratin, a revolutionary technology that captures the native form and function of keratin proteins, thereby preserving their bioactivity. From acute wounds, such as burns, to chronic wounds caused by skin diseases like Epidermolysis Bullosa (EB), this proprietary technology has demonstrated the ability to activate keratinocytes, promote epithelialization, and enhance production of important basal membrane proteins.

This is where healing begins.

Replicine Bioactive Keratin Mechanism of Action


Prior to application, qualified healthcare professionals (HCP's) should confirm or clarify coding and coverage with their respective local Medicare contractor, as each contractor may have differing formal or informal coding or coverage policies. HCP's should also obtain prior authorization from private payers or Medicaid, where applicable.

HCP's are responsible for accurate documentation of patient conditions and appropriate reporting of procedures and products.

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Sample Treatments

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Indications and Contraindications

KERAMATRIX products are indicated for the management of wounds including:

  • Partial and full-thickness wounds

  • Pressure ulcers

  • Venous ulcers

  • Chronic vascular ulcers

  • Tunneled and/or undermined wounds Diabetic ulcers

  • Trauma wounds (abrasions, lacerations, second-degree burns, skin tears)

  • Draining wounds

  • Surgical wounds (donor sites/grafts, post-Mohs' surgery, post-laser surgery, podiatric, wound dehiscence)

KERAMATRIX products are contraindicated in patients with a known sensitivity to Keratin.

KERAMATRIX products are not indicated for third degree burns. 

Please review the Local Coverage Determination (LCD) specific to the Medicare contractor that processes your claims, the medical policies of the private payers in your geographic area, and your state's Medicaid policies to confirm the indications that are covered.

Peer Review Publications

1. A. Batzer, C Marsh, R Kirsner The Use of Keratin Based Wound Products on Refractory Wounds, Int Wound J. 2014 Feb 28. doi: 10.1111/iwj.12245.
2. N Jina, C Marsh, M Than, H Singh, S Cassidy J Simcock1 Keratin Gel Improves Poor Scarring following Median Sternotomy, ANZ Journal of Surgery, 2014
3. G Sussman, Advances in Wound Dressing Technology, Wounds International, Dec 2013, vol 4, issue 4, p12-14.
4. A Davidson, N Jina, C Marsh, M Than and J Simcock, Do Functional Keratin Dressings Accelerate Epithelialization in Human Partial Thickness Wounds? A Randomized Controlled Trial on Skin Graft Donor Sites eplasty13e45 aug 2013.
5. M P Than, R A Smith, C Hammond, R Kelly, C Marsh, A D Maderal, R S Kirsner. Keratin-based Wound Care Products for Treatment of Resistant Vascular Wounds. J Clin Aesthet Dermatol. 2012 Dec;5(12):31-5.
6. A C Vivas, A D Maderal, M P Than, R S Kirsner. Letter: Designing clinical trials to bring wound products to market Int Wound J. 2013 Feb;10(1):114-5. Epub 2011 Dec 14.
7. R Kirsner, S Cassidy, C Marsh, R Kelly, Use of a Keratin-Based Wound Dressing in the Management of Wounds in a Patient with Recessive Dystrophic Epidermolysis Bullosa, Adv Skin and Wound Care 2012;25:400-3.
8. P M Pechter, J Gil, J Valdes, M Tomic-Canic, I Pastar, O Stojadinovic, R S Kirsner and S C Davis. Keratin dressings speed epithelialization of deep partial-thickness wounds. Wound Repair and Regeneration, (2012) vol 20, pp 236-242.
9. L. Tang, J. Ollague Sierra, R. Kelly, R. S. Kirsner, J. Li, Wool-derived keratin stimulates human keratinocyte migration and types IV and VII collagen expression, Experimental Dermatology, 21, 5, 2012, DOI: 10.1111/j.1600-0625.2012.01505.x
10. M Than, R Smith, S Cassidy, R Kirsner, R Kelly, C Marsh, A Maderal, Use of Keragel in the Management of Recessive Dystrophic Epidermolysis Bullosa. Journal of Dermatological Treatment, epub 21 jan 2012.
11. C Hammond, M Than, J Walker. From the laboratory to the leg: Patient's and nurses perceptions of product application using three different dressing formats, Wound Practice and Research, 18, 4, 189-195, November 2010.
12. R Kirsner Use of topical keratin gel by patients with epidermolysis bullosa, Journal of the American Academy of Dermatology, March 2009 (Vol. 60, Issue 3, Supplement 1, Page AB202)
13. S Davis, R Perez, Y Rivas, J Gil, J Valdes, and R Kirsner, The effect of a keratin based dressing on the epithelialization of deep partial thickness wounds, Journal of the American Academy of Dermatology March 2009 (Vol. 60, Issue 3, Supplement 1, Page AB201)

Conference Presentations and Posters

1. J Denyer, C Marsh, R Kirsner Use of a keratin gel in the management of Epidermolysis bullosa, Proceedings of SAWC spring 2014, Orlando, Fl, April 2014
2. F Loan, C Marsh, S Cassidy, J Simcock, Keratin dressings for effective wound care management partial thickness burn injuries, Proceedings of SAWC, Orlando, Fl, April 2014.
3. R J Snyder, M Moradi, C Marsh, R Kelly, A Case Study Series Showing Exceptional Healing on Hard to Heal Chronic Wounds with Keratin, Proceedings of SAWC spring 2014, Orlando, Fl, April 2014
4. J Denyer keragelT for management of Epidermolysis Bullosa, a case study series. EWMA 2013.
5. S Cassidy, F Loan, J Simcock, C Marsh, Use of Functional Keratin on Superficial and Partial Thickness Burns, NZWCS May 2013.
6. C Marsh Clinical evaluations of nz-developed, keratin-based wound healing products in innovative, early-adopter wound healing centres in usa, NZWCS May 2013.
7. N Blasiole, E Mostow, Use of keratin gel technology to speed healing of hard to heal wounds. Proceedings of SAWC, Denver, CO, May 2013.
8. A Davidson , J Simcock, H Jina and C Marsh , A Pilot Study Of Keratin Dressings In Skin Graft Donor Site Epithelialisation, proceeding of NZWCC conference, Dunedin, NZ, Nov 2011.
9. H Jina, J Simcock, M Than, S Cassidy and C Marsh The effect of using a keratin bases gel on median sternotomy scarring, proceedings of Plastic Surgery Congress, July 2011, Gold Coast, Australia
10. A Arbuckle, A case study series of the management of Epidermolysis Bullosa using Keragel T, Society of Paediatric Dermatology Portland USA, July 10
11. R Kelly, C Marsh, M Than, S Cassidy, RA Smith, Topical keratin for improvement of skin and wound healing, New Zealand dermatology society conference, May 10
12. Management of recessive dystrophic epidermolysis bullosa using keragelT, DEBRA patient care conference, Cincinnati USA, April 10.
13. Management of epidermolysis bullosa simplex using keragelT, DEBRA patient care conference, Cincinnati USA, April 10
14. M Than, C Hammond, R A. Smith, C Marsh, R Kelly, P Rohricht, R S Kirsner, A Prospective Pilot Study of Keratin Dressings: Effectiveness on Refractory (Large and of Long Duration) Venous Leg Ulcers SAWC, April 2010, Orlando, Florida.
15. R Perez, R Kirsner, J Gil, J Valdes, S Davis, Evaluation of the effects of two keratin formulations on wound healing and keratin gene expression in a porcine model, Symposium on Advanced Wound Care conference presentation, April 2009.
16. W Thompson, S Hanneke, M Compton, L Burrage, K Butler, A keratin matrix interface in negative pressure wound therapy, Clinical Symposium on Advances in Skin and Wound Care, Las Vegas Oct 26-30, 2008.
17. S Cassidy, M Than, Improved healing of Epidermolysis Bullosa wounds using a novel keratin gel technology, Australian Wound Management Association conference proceedings, May 2008.
18. J Randles, The use of a keratin dressing on a recalcitrant venous leg ulcer, Australian Wound Management Association conference proceedings, May 2008.
19. K Balance, C Marsh, M Than, Improved healing of a diabetic foot ulcer using new keratin dressing technology, Australian Wound Management Association conference proceedings, May 2008.
20. R Kelly, F Sigurjonsson, R A Smith, A Ali, M Than, R Mcpherson, C Hammond, Keratin biopolymer dressings for wound care, Symposium on Advanced Wound Care conference proceedings, 2006.