Healing by Design

Keramatrix® is an absorbable matrix enriched with pharmaceutical-grade keratin protein that delivers Replicine™ Bioactive Keratin as it dissolves into the wound. It is presented sterile in peel-open packages for single use. Keramatrix® is indicated for1:

  • Acute surgical wounds
  • Partial and full thickness wounds
  • Donor sites/grafts
  • Podiatric wounds
  • Wound dehiscence
  • Diabetic ulcers
  • Chronic vascular ulcers
  • Venous ulcers
  • Pressure ulcers
  • Traumatic wounds
  • First- and second-degree burns

Due to the unique biological function of keratin protein, Keramatrix® delivers a level of performance typically associated with high cost biological products in a much lower cost and more convenient format.2

Improved Wound Healing

Keramatrix® has demonstrated faster epithelialization rates and more robust skin after healing in numerous clinical studies. In vitro studies have shown that Replicine™ Bioactive Keratin increases the rates of proliferation and migration of keratinocyte cells, specifically encouraging keratinocyte cells into an active healing phase earlier than when Keramatrix® is not used.3,4 This means Keramatrix® can speed healing, improve the healed outcome, and reduce cost of care in the following treatment areas1,2:

  • Chronic Wound Care
  • Burn Treatment
  • Donor Site Treatment
  • Skin Tears

See our Clinical Data

See Prescribing Information here.




No adverse events have been reported. Available in:
– 2”x2” (5cmx5cm), NDC 71474-303-55
– 4”x4” (10cmx10cm), NDC 71474-303-50

Q4165:  Skin Substitute, KERAMATRIX, per square centimeter

See our complete reimbursement guide Information.


(Note: always handle using aseptic technique.)

Watch our How to Use Video.

Wound Bed Preparation and Application

  1. Prepare the wound area using standard debridement methods; the wound may be surgically debrided to ensure the wound edges contain viable tissue.
  2. Cut the dry Keramatrix® sheet into a piece slightly larger than the outline of the wound area. If the wound is larger than a single sheet, multiple sheets may be used, overlapping edges as necessary.
  3. For a wound with a low-level of exudates, hydrate Keramatrix® by soaking it in sterile saline solution for 2 minutes prior to application.
  4. Place the edge of the sheet in contact with intact tissue and smooth the matrix so that it contacts the underlying wound bed. If multiple sheets are used, overlap adjoining sheets to provide coverage of the entire wound. Secure with physician’s preferred method of fixation (steri-strips, sutures, staples, clips).
  5. After application, use an appropriate non-adherent, occlusive secondary dressing to maintain a moist environment. Ensure the matrix is well restrained.

Matrix Changes and Reapplications

  1. Change Keramatrix® as necessary every 4 to 5 days or as determined by the healthcare provider. Do not remove existing gel or matrix areas. The matrix will carmelize into a gel and have an off-white or light brown color.
  2. Once cleansed with a sterile saline solution, Keramatrix® may be reapplied. Ensure that there are no bleeding areas and the wound edges are clean.
  3. For a wound with a medium to high level of exudates, place the edge of the sheet in contact with intact tissue and smooth the dressing so it contacts the underlying wound bed. Small openings can be cut into the sheet prior to application to allow adequate drainage and ensure tissue matrix contact with the wound bed.
  4. Carefully document healing progression using customary healing parameters. Proceed with reapplication of appropriate non-adherent occlusive secondary dressing and maintain a moist environment.
  5. If infection, excessive redness, blistering, or allergic reaction occurs, Keramatrix® should be removed.



CONTRAINDICATIONS: Keramatrix should not be used in patients with known sensitivity to keratin or any of the excipients.


1.Keramatrix® [package insert.] Molecular Biologicals: Pasadena, TX; 2017. 2. Loan F, Cassidy S, Marsh C, et al. Keratin-based products for effective wound care management in superficial and partial thickness burns injuries. Science Direct. 201;42:541-547. 3. Batzer AT, Marsh C, Kirsner RS. The use of keratin-based wound products on refractory wounds. Int Wound J. 2016;13(1):110-115. 4. Davidson A, Jina NH, Marsh C, et al. Do functional keratin dressings accelerate epithelialization in human partial thickness wounds? A randomized controlled trial on skin graft donor sites. Eplasty. 2013;3:375-381. 5. Denyer J, Marsh C, Kirsner RS. Keratin gel in the management of Epidermolysis bullosa. J Wound Care. 2015;24(10):446-450.