Acute Woundcare

Replicine™ Bioactive Keratin in Acute Woundcare


Replicine™ Bioactive Keratin Technology Accelerated Closure and Epithelialization

In an in vivo study, Replicine™ Bioactive Keratin achieved statistically significant differences on Day 5. Improvements in healing rate lead to an estimated 2-day improvement in healing time, with an associated reduction in risk of infection and other complications.


Replicine™ Bioactive Keratin Technology Increased Keratinocyte Migration

In an in vitro scratch migration assay test examining the effects of keratin on the migration of keratinocytes, Replicine™ Bioactive Keratin was shown to promote keratinocyte migration, as demonstrated by keratinocytes entering both the activated phase and the migratory phase sooner than the positive control group.1

Keratinocytes grow faster across a scratch made in a confluent culture in vitro in the presence of Replicine™ Bioactive Keratin compared to no keratin present.1


In this same study, there was an increase in production of basal membrane proteins of types IV and VII collagens in the presence of Replicine™ Bioactive Keratin.2


Improved Scar Outcomes

Replicine™ Bioactive Keratin is a simple, well-tolerated treatment for reduced problematic scarring following surgery. In a 20-patient clinical case series of skin tears, the proportion of patients who experienced poor scarring (MSS score of 13 or greater) was 20% lower with Replicine™ Bioactive Keratin compared to control at 6 months. Improvements in scar characteristics—including contour, texture, and irregularity—were consistent between scar scoring systems and between patient and observer. In addition, there were no post-operative complications nor any adverse events associated with Replicine™ Bioactive Keratin treatment.3


References

1.Pechter PM, Gil J, Valdes J, et al. Keratin dressings speed epithelialization of deep partial-thickness wounds. Wound Rep Reg. 2012;20:236-242. 2. Tang L, Sierra JO, Kelly R, et al. Wool-derived keratin stimulates human keratinocyte migration and types IV and VII collagen expression. Exper Derm. 2012(21):456-476. 3. Jina NH, Marsh C, Than M, et al. Keratin gel improves poor scarring following median sternotomy. ANZ J Surg. 2015;85(5):378-380.