Burns and Donor Sites

Replicine™ Bioactive Keratin for Burn Treatment and Donor Sites


Replicine™ Bioactive Keratin Facilitates Healing of Burns With Minimal Scarring

Up to 70% of patients develop hypertrophic scars after burns, characterized by decreased collagenase activity and collagen breakdown. The prevention of hypertrophic scarring is critical to improve outcomes and quality of life.1

Superficial and partial thickness burns account for a large share of burn presentations in the hospital setting, yet there is an unmet need for products that expedite the healing process.2 Mismanagement of donor site wounds can lead to drying of the wound, increased time to healing, and deeper scarring.3 However, application of dressings that provide a warm, moist healing environment has been shown to help prevent cell dehydration and death, promote angiogenesis, and improve reepithelialization and growth factor.4

Replicine™ Bioactive Keratin is an easy-to-use, effective and convenient treatment for improved burn wound management, rapidly providing a robust protective barrier against trauma and bacterial colonization. It maintains a moist healing environment, encouraging keratinocyte proliferation and migration, which accelerates the healing process.2


Healing of Burns With Minimal Scarring With Replicine™ Bioactive Keratin

In a 40-patient study on partial thickness burns, patients treated with Replicine™ Bioactive Keratin experienced faster epithelization rates and less severe scarring and pigmentation effects than the control group. Replicine™ Bioactive Keratin was well tolerated by patients with minimal pain or itch, and patients were relatively quickly able to return to regular activities of daily living.2


Significantly Reduced Cost of Woundcare Management with Replicine™ Bioactive Keratin

In this same 40-patient study, use of Replicine™ Bioactive Keratin significantly reduced cost of woundcare management by nearly half in superficial and partial thickness burn injuries. The control group utilized substantially more hospital resources vs the Replicine™ Bioactive Keratin treatment group, including increased2:

  • Number of hospital outpatient clinic appointments
  • Hospitalizations for dressing changes and surgical management under sedation
  • Courses of prescribed antibiotics

Significant Increase in Epithelialization Rates of Donor Site Wounds With Keramatrix®

In a randomized, blinded, controlled study of 26 split skin graft donor site wounds, patients treated with Keramatrix® demonstrated statistically significant improvement in epithelialization after 7 days compared to standard of care.  Treatment with Keramatrix® also reduced healing time and potential complications, such as infection or scarring.5

Epithelialization of a typical donor site 7 days after surgery.5


References

1.Finnerty CC, Jeschke MG, Branski LK, et al. Hypertrophic scarring: the greatest unmet challenge after burn injury. Lancet. 2016;388:1427-1436. 2. Loan F, Cassidy S, Marsh C, et al. Keratin-based products for effective wound care management in superficial and partial thickness burns injuries. Science Direct. 201;42:541-547. 3. Achora S, Muliira JK, Thanka An. Strategies to Promote Healing of Split Thickness Skin Grafts: An Integrative Review. J Wound Ostomy Continence Nurs. 2014;41(4):335-339. 4. Nicks BA, Ayello EA, Woo K, et al. Acute wound management: revisiting the approach to assessment, irrigation, and closure considerations. Int J Emerg Med. 2010(3):399-407. 5. Davidson A, Jina NH, Marsh C, et al. Do functional keratin dressings accelerate epithelialization in human partial thickness wounds? A randomized controlled trial on skin graft donor sites. Eplasty. 2013;3:375-381.