Chronic Woundcare

Replicine™ Bioactive Keratin in Chronic Woundcare

Nearly 7 million Americans suffer from chronic wounds, such as foot ulcers and venous leg ulcers.1 In fact, venous leg ulcers are the most common type of chronic wound, with an incidence of 2.5 million each year.2

Despite optimal care, healing chronic wounds continues to be a major challenge, as many wounds remain recalcitrant. The fact is, more than 25% of venous leg ulcers remain unhealed even after 6 months of standard treatment.3

Chronic, recalcitrant wounds are associated with increased mortality and represent a major economic burden. In fact, they are the most costly skin diseases, estimated at nearly $25 billion annually. The overall burden of chronic woundcare includes treatment costs, loss of productivity for patients and their families for care for them, and diminished quality of life.1

Despite optimal care, healing chronic wounds continues to be a major challenge, as many wounds remain recalcitrant.3

  • Less than 1/3 of patients with diabetic foot ulcers receiving standard treatment are healed even after 20 weeks
  • More than 25% of venous leg ulcers remain unhealed even after 6 months of standard treatment

There still remains a significant segment of patients with a range of ulcers who do not respond to compression therapy alone, and keratin-based dressings have the potential to improve healing outcomes and avoid the need for surgery.3

Highly Favorable Response in Hard-to-Heal Wounds

Replicine™ Bioactive Keratin treatment was used in a 45-wound case series of mixed etiology chronic wounds, including venous leg ulcers and diabetic wounds. 82% of hard-to-heal wounds (>2 month duration) achieved a highly favorable response with 64% completely healing and the remaining 18% experiencing a wound size reduction of ≥50%.1


8-month duration wound of patient with. Rheumatoid arthritis prior to treatment with Replicine™ Bioactive Keratin.1 Wound with dressing in place at 1 week.1 Wound after 9 weeks of treatment with Replicine™ Bioactive Keratin.1


Complete Healing After 10 Weeks

Large recalcitrant ulcer (12 cm2) in a man 62 years of age progressed from a nonhealing to a healing wound with the development of a healthy granulating base. Epithelializing margins completely healed after 10 weeks. Further dressing was required after patient sustained trauma to that area, which completely healed after 16 weeks and remained healed at 6 months.3

Chronic venous leg ulcer present for 24 weeks prior to Replicine™ Bioactive Keratin treatment.3 Epithelializing margins completely healed following 10 weeks of Replicine™ Bioactive Keratin treatment and remained healed at 6 months.3

Healing Demonstrated in Long Duration Wounds

Replicine™ Bioactive Keratin treatment was used in a 23 patient case series of long duration venous and mixed arterial/venous ulcers.4 77% of large (>5 cm2), long duration (>6 months) wounds healed with Replicine™ Bioactive Keratin treatment4,5 compared to an historical expectation of 13% for this wound type.5 In addition, 86% of nurses and 91% of patients indicated a preference for Replicine™ Bioactive Keratin treatment over conventional therapy.4

Patients and Healthcare Professionals Prefer Replicine™ Bioactive Keratin Treatment

In a study assessing patient and nurse acceptability of leg ulcer treatments, respondents “preferred” or “very much preferred” Replicine™ Bioactive Keratin over other dressings because Replicine™ Bioactive Keratin was easy to apply or remove, quicker to change, comfortable, and stayed in place well.4

Nurses Prefer Replicine™ Bioactive Keratin3

Overall, how preferable was the new

dressing compared to the old one?

95% preferable/much more preferable
Overall, how easy was the dressing to apply? 96% very easy/easy to apply
The patient appeared to find keratin
dressing was comfortable to have in place
94% strongly agree/agree
It took less time for the dressing to bedone
(compared to previous ulcer dressing)
89% strongly agree/agree
Patients know how to look after their dressing 99% strongly agree/agree
I would be happy to use the dressing again 95% strongly agree/agree


1.Batzer AT, Marsh C, Kirsner RS. The use of keratin-based wound products on refractory 2. Int Wound J. 2016;13(1):110-115. 3. Macdonald JM, Geyer MJ. Wound and Lymphoedema Management. World Health Organization. 2010. 4. Than MP, Smith RA, Hammond C, et al. Keratin-based wound care products for treatment of resistant vascular wounds. J Clin Aest Derm. 2012;5(12):31-35. 5. Hammond CE, Than M, Walker JW. From the laboratory to the leg: Patients’ and nurses’ perceptions of product application using three different dressing formats. Wound Prac Res. 2010;18(4);189-195. 6. Margolis DJ, Berlin JA, Strom BL. Which venous leg ulcers will heal with limb compression bandages? Am J Med. 2000;(109):15-19.