Diabetic Foot Ulcers

Replicine™ Bioactive Keratin for Diabetic Foot Ulcers

Diabetic Foot Ulcers: Chronic, Complicated, and Costly

Annually, foot ulcers develop in 9.1M-26.1M people with diabetes worldwide1.

  • Between 19% and 34% of persons with diabetes will be affected by a foot ulcer
  • Roughly 40% of patients have a recurrence within 1 year after healing of an ulcer, and almost 60% within 3 years

Foot ulcers are a significant predictor of future lower-extremity amputation in patients with diabetes. In fact, approximately 14-24% of patients with a foot ulcer will require amputation2. When it comes to cost, it’s important to note that in the US, more than $58 billion is spent annually on lower extremity-related diabetes care.1

Replicine™ Bioactive Keratin Delivers Superior Efficacy in Diabetic Foot Ulcers

In patients with diabetic foot ulcers, even those known to be slow to heal, Replicine™ Bioactive Keratin delivers superior efficacy compared to standard of care (SOC). In a case series of patients with type 2 diabetes and chronic diabetic foot ulcers with a wound duration ranging from 6 weeks to 4 months, treatment with Replicine™ Bioactive Keratin for up to 10 weeks was shown to improve healing relative to SOC.3


Type 2 diabetes non-healing diabetic foot ulcer of6 weeks duration in a male 56 years of age.3 After 4 weeks following application of Replicine™ Bioactive Keratin treatment.3 Complete healing demonstrated after 7 weeks of Replicine™ Bioactive Keratin treatment.3

42-year old male with type 2 diabetes non-healing incision of 3 months duration following exostectomy and bursa excision plantar on left foot.3 After 4 weeks following application of Replicine™ Bioactive Keratin treatment.3 Healed wound after 6-weeks of Replicine™ Bioactive Keratin treatment.3


1.Armstrong DG, Boulton AJM, Bus SA. Diabetic Foot Ulcers and Their Recurrence. N Engl J Med. 2017;376(24):2367-2375. 2. American Diabetes Association. Consensus development conference on diabetic foot wound care. Diabetes Care. 1999;22(8):1354-1360. 3.http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/endocrinology/prevention-treatment-diabetic-leg-and-foot-ulcers/#bib4. 4. Walid F, Patel SR, Wu S. A new approach to diabetic foot ulcers using keratin gel technology. Presented at: Center for Lower Extremity Ambulatory Research; North Chicago, IL; 1-25.