Mechanism of Action

Replicine™Bioactive Keratin

 

Providing an Ideal Environment for Healing

The unique Replicine™ Bioactive Keratin peptides and molecules provide a wholly organic, biocompatible cell-growth substrate or scaffold for growth of new tissue, which is reabsorbed into the developing tissue in the wound.  The keratins absorb and interact with wound fluids, facilitating a moist wound-healing environment while promoting tissue healing.1 Slow absorption of the proteins into the wound bed facilitates bioavailability for a minimum of 2-4 days.2

 

 


Unique Mechanism of Action—Replicine™ Bioactive Keratin

  • Proliferation and migration of keratinocyte cells is often a rate limiting step in epithelialization and wound closure2,3
  • Replicine™ Bioactive Keratin regulates cell growth and migration via the Akt/mTOR signaling pathway,4 activating keratinocyte cells present in the wound and stimulating them to quickly enter a hyperproliferative phase, essential for wound healing3,5,6

  • Stimulation of keratinocytes achieved by Replicine™ Bioactive Keratin accelerates epithelialization, resulting in improved wound healing3,6

  • Replicine™ Bioactive Keratin also has the effect of increasing levels of Collagen IV and VII, critical for basal membrane integrity.

These basal membrane collagens join the dermal and epidermal junction to build a strengthened, robust, and healed skin surface7


References

1.Loan F, Cassidy S, Marsh C, et al. Keratin-based products for effective wound care management in superficial and partial thickness burns injuries. Science Direct. 2016;42:541-547. 2. Batzer AT, Marsh C, Kirsner RS. The use of keratin-based wound products on refractory wounds. Int Wound J. 2016;13(1):110-115. 3. Walid F, Patel SR, Wu S. A new approach to diabetic foot ulcers using keratin gel technology. Presented at: Center for Lower Extremity Ambulatory Research; North Chicago, IL; 1-25. 4. Davidson A, Jina NH, Marsh C, et al. Do functional keratin dressings accelerate epithelialization in human partial thickness wounds? A randomized controlled trial on skin graft donor sites. Eplasty. 2013;3:375-381. 5. Jina NH, Marsh C, Than M, et al. Keratin gel improves poor scarring following median sternotomy. ANZ J Surg. 2015;85(5):378-380. 6. Pechter PM, Gil J, Valdes J, et al. Keratin dressings speed epithelialization of deep partial-thickness wounds. Wound Rep Reg. 2012;20:236-242. 7. Tang L, Sierra JO, Kelly R, et al. Wool-derived keratin stimulates human keratinocyte migration and types IV and VII collagen expression. Exper Derm. 2012(21):456-476.